![]() ![]() ELISA results illustrated that interleukin (IL)‑1, IL‑10 and tumor necrosis factor‑α (TNF‑α) levels were elevated, whereas IL‑12 level was reduced in lung tissues of the asthma and 10 µmol/l RES groups whilst the 50 µmol/l RES group demonstrated the opposite trend. Treatment with 50 µmol/l RES significantly decreased the thicknesses of the airway wall and smooth muscle. The number of inflammatory cells in BALF extracted from rats of the asthma and 10 µmol/l RES groups was higher compared with the 50 µmol/l RES group. Masson staining indicated that there was an increased airway collagen deposition area in the asthma and 10 µmol/l RES groups compared with the 50 µmol/l RES group. ![]() H&E staining demonstrated that multiple inflammatory cell infiltration into the rat airway epithelium of the asthma group occurred whilst the 50 µmol/l RES group displayed alleviated pathological lesions. Reverse transcription‑quantitative polymerase chain reaction was performed to detect high mobility group box 1 (HMGB1), Τoll‑like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88) and NF‑κB expression in asthmatic and healthy children, as well as rats of the different groups. The blood serum of asthmatic and healthy children was also collected for analysis. Levels of inflammatory factors in lung homogenate were detected via ELISA. Pathological lesions in lung tissues were accessed by hematoxylin and eosin (H&E), and Masson's trichrome staining. The amount of inflammatory cells in rat bronchoalveolar lavage fluid (BALF) was detected. Rats were randomly assigned into sham, asthma, 10 µmol/l RES and 50 µmol/l RES groups. An asthma rat model was induced by ovalbumin (OVA) treatment. The aim of the present study was to explore the protective role of resveratrol (RES) in asthma‑induced airway inflammation and remodeling, as well as its underlying mechanism. ![]()
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