![]() ![]() We also identify the gaps in our current understanding and highlight important topics for future research. ![]() In addition we describe the exciting progress that has been made in the development of Hsp90 inhibitors, which are now showing promise in the clinic for cancer treatment. Here we review the biology of the Hsp90 molecular chaperone, emphasizing recent progress in our understanding of structure–function relationships and the identification of new client proteins. Targeting the Molecular Chaperone Hsp90 in Cancer: What Does the Biology Tell Us TAT 2011. Here, we demonstrate that HSP90 plays a powerful oncogenic role by inducing p14ARF degradation, which prevents cellular senescence. The cycle is also regulated by a group of co-chaperones and accessory proteins. ![]() Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis at the N-terminus. Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent abstract. By this means, Hsp90 displays a multifaceted ability to influence signal transduction, chromatin remodelling and epigenetic regulation, development and morphological evolution. It interacts with ‘client proteins’, including protein kinases, transcription factors and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Beyond these specific regulators, the Hsp90 molecular chaperone, a member of the general cellular protein-folding machinery, also plays a fundamental role in the regulation of many kinases. The molecular chaperone Hsp90 (90 kDa heat-shock protein) is a remarkably versatile protein involved in the stress response and in normal homoeostatic control mechanisms. ![]()
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![]() ![]() On some newer Intel devices, it may be necessary to set the `Computer\HKEY_CURRENT_USER\Software\Topaz Labs LLC\Topaz Video AI\OVUseDeviceIndex` registry entry. The following options can be used to take advantage of hardware acceleration features from different GPU manufacturers: Similarly, different encoders support different options, so you may need to tweak settings on different machines. However, different graphics cards may support different encoders and options. TVAI is used as an FFmpeg filter, and all models will work on graphics devices from Intel, AMD, Nvidia, and Apple using a command like this example: -vf "tvai_up=model=aaa-10:scale=2" In most cases, this value should not be changed from its default setting.This variable should be set to the folder containing the model definition files (.json), your authentication file ( auth.tpz), and the tvai.tz file.Chosen during initial installation (Windows).A location with ~80 GB of free space will work best. This variable should be set to the folder where you want model files to be downloaded.Stabilization tvai_cpe + tvai_stb Video AI Command Line Usage If you log out and need to log back in without launching the GUI. Please see the Environment Variables section below.Ĭd /Applications/Topaz\ Video\ AI.app/Contents/MacOS You must manually set the TVAI_MODEL_DATA_DIR and TVAI_MODEL_DIR environment variables if launching without the GUI. The next time you want to launch the CLI without the GUI, follow the steps below: This eliminates the need to use a command to log into the app and will allow you to launch the terminal directly from the GUI.Īfter logging in, select Process > Open Command Prompt, this will set the model directory automatically. Getting Started with CLIīefore using the CLI for the first time, we recommend launching the GUI and logging into the app. ![]() This article will outline the basic functions for TVAI’s CLI, however, you will want to familiarize yourself with FFmpeg commands for more complex use cases. There is no need to install FFmpeg, it is automatically included with the TVAI installer. ![]() The majority of the commands for this build will be FFmpeg commands. We highly recommend using the app’s user interface for those not comfortable working in a command terminal. This is designed for advanced users comfortable working in such an environment and offers more flexibility in customizing a variety of scripted processes. Topaz Video AI supports executing scripts using a command line interface. ![]() ![]() ![]() Please note that you are responsible for the cost of shipping the return or exchange to us. If an exchange was requested you will receive an email notification with either tracking information or your merchandise credit to be used at. Please allow up to five business days for the refund to be processed by your bank. If your return qualifies for a refund, your refund will be applied to the original form of payment. Once the return has been received and inspected in our warehouse you’ll receive an email notification confirming your return. Turnaround time for processing your return is generally 3 business days, but can fluctuate depending on the time of year. Please mail your return or exchange to the address below and include a reference to your order number. We are unable to accept returns and exchanges of excessively used products or products not purchased from. We are unable to honor exchanges on International and Puerto Rico shipments. We’d be happy to exchange any gently used products for store credit to if received within 30 days from the shipment date, for domestic USA shipments only, in addition to Alaska and Hawaii. Products purchased in bundles cannot be returned or exchanged. Unused product can be returned for either store credit to or a refund of the purchase price (not including shipping). If for any reason you are unhappy with your purchase from, we will gladly accept your return if received within 30 days from the shipment date. Please note the below policy does not apply for BOGO's, bundles, or any value sets. We love new makeup, too! To track your order, click here and sign into your account. International shipping fees may vary during sales, Holidays, or promotional events, duties and taxes are not included in advertised shipping rates on and are the responsibility of the receiving customer. If you have questions regarding the duty or tax rate for your package, please contact your local postal service for more information. TheBalm Standard international shipping is $30 or free for orders over $150. Puerto Rico shipping fees may vary during sales, Holidays, or promotional events. TheBalm Standard Puerto Rico shipping is $30 or free for orders over $150. FLASH SALE: $5 shipping charge for orders under $50, Free shipping for orders over $50. Please see our Flash Sale FAQ's page for details)! Our standard processing time is between 2-7 business days processing times may vary during sales, Holidays, or promotional events, and may be further impacted by UPS, USPS or Fedex delivery times during COVID-19. TheBalm currently offers free standard shipping on all domestic U.S orders, in addition to Alaska and Hawaii (exceptions include Flash Sales and other site wide promotions. No adjustments can be made on orders once they are placed. No pricing adjustments can be made on orders prior to sale or after sale. Our standard processing time is between 2-7 business days processing times may vary during sales, Holidays, or promotional events. We hate to make you wait, especially on new makeup! So at theBalm, we strive to process orders as soon as they’re received. ![]() ![]() Some students handing in their AI-generated thesis have the same intention.ĪI Cheat 1: Long form content - combined from multiple prompts What “percent human” is acceptable for professional marketing content? What “percent AI-generated” is acceptable for CVs, glossaries, and sales pages? Humanity is very early in discovering new opportunities provided by AI, but it’s apparent that we want to know from a source: “ are you actually human?”Īlready today, there are a couple of tricks that copywriters can use to cheat on AI Content Detectors, but ultimately their clients order the copy. What quality can we expect, from which publisher, on which topic if content production can so easily be automated by factor 10 to 100? Who takes care of factual correctness when the AI starts to “hallucinate” details, something that is easily possible, and in fact, “ a feature, not a bug,” a parameter to help increase the “creativity” of language models On the other hand, copywriters argue that the machine-learning tools that help them produce their work are just tools, like calculators and Excel Accounting Software for bookkeepers.Īnd there is of course, the audience that the articles are written for. ![]() ![]() At least, that is the standard expectation from the SEO agency or brand hiring copywriters. However, when paid by SEO agencies to write quality, unique content, copywriters or content writers should not be using a such mechanic and replaceable AI Text Generators, be it GPT-3 based, GPT3.5 or ChatGPT, without disclosure or agreement. More modern versions like GPT3.5 or ChatGPT have shown us the almost limitless possibilities to use such large language models (LLM) to create content with WOW effects. Let’s face it - (almost) everyone is using GPT-3 tools like WriteSonic, Jasper.ai, or Copy.AI to help create their marketing content. ![]() Tricking AI Content Detection Tools - is that possible? ![]() ![]() Flip pictures or rotate layers to change the orientation. Position: Drag the picture around to place it in the right position.Size: Use the corner handlers to shrink or expand the image to take up less or more of the screen.Step 3: Arrange the pictures in a collageĪfter you have all the picture layers visible on the Kapwing canvas, size and position each picture in the correct layout. Or, if you want to remove the extra padding, click the "Remove Padding" button to bring the area tight around your layers. Add more area around your pictures with the "Add padding" buttons. Upload video clips, type animated text, overlay a quote, or import moving stickers with the GIPHY plugin to bring your picture collage to life.Īs you upload, you may need more canvas space. Kapwing supports collages with videos and GIFs also. To find freely usable images, click " Plugins" and browse pictures from Pixabay, Pexels and Unsplash. Find transparent GIFs by adding "GIF" to your search query. Type in what photo you want to find and browse through the results to find the best picture for your collage. In Kapwing, you can also search for images using the "Images" tool. Drag and drop the picture files onto the Kapwing Studio canvas, click upload or paste an image URL. There are a few ways you can import pictures for your collage. Alternatively, you can upload a photo or image to act as the backdrop for all of your pictures in the collage. In my example, I selected a bright blue for the background. You can select a background color, either by choosing a preset option or entering a custom hex code. Next, design the background of the collage. For example, creators can change to 9:16 to make a picture collage for their Instagram Story or 16:9 to make a collage thumbnail for YouTube. Use the tools in the editing panel to change the color and size of the background. The default background is a white 1:1 square. Head to Kapwing to "Get Started" and click to open a blank canvas. The first step is to open your digital collage canvas. If you can relate, follow the steps below to get started or scroll down to the next section. I have a larger screen to work with, quick access to each tool, and more storage if I want to download my work. I usually prefer working on a desktop to assemble creative projects like collages. How to Use a Free Online Collage Maker on Desktop With this website, you can start with a collage template or design a custom collage format. In this article, I'll show you how to make a collage with pictures on desktop and mobile using a free online collage maker called Kapwing. Also, it supports GIF and video collage layers too. It has features for adding text, searching for images, and positioning the layers where you want them. ![]() I recommend Kapwing's free Collage Maker tool because it's free, works on every device, and doesn't require you to download any software. You need to find a good product with a large enough digital space for collaboration. Once you have a creative vision, it can be hard to choose a collage. If you place photos side by side, a picture collage is also the ideal way to compare two images, events, moments, or people. Multimedia collages are a festive, fun way to share memories with a friend, celebrate a special event, and reminisce on social media. In this article, I show you how to use a free online video editor called Kapwing to make a free collage from pictures. ![]() ![]() ![]() The Flexible Drill Bit Extension is a professional-grade tool, ideal for those who deal with engine stricture uninstall screws. The metal hose can be bent up to 300 degrees, allowing it to rotate in various directions, making it easy to access hard-to-reach corners and tight spaces that ordinary screwdrivers cannot handle. This tool is an essential assistant for any screwdriver job, especially for auto repair tasks. Its hexagon handle (1/4 handle) and 6.35mm (1/4 ") screwdriver head are designed with convenience in mind, while the metal hose measures either 20cm/7.9" or 30cm/11.8", providing ample length to reach tight spaces. The Flexible Drill Bit Extension is a durable and sturdy tool that boasts high hardness and a clear angle, making it easy to use and control. Get one for yourself today and see the difference it can make! 3. Flexibit: Extension Holder For Quick Bit Change. It is durable, easy to use, and can save you time and effort while working on your projects. The Flexible Screwdriver is a must-have tool that offers convenience, flexibility, and functionality. ![]() Its ability to bend and extend to more corners and narrow places makes it an invaluable tool for any mechanic or DIY enthusiast. This tool is a great assistant for car engine repair, especially when it comes to uninstalling screws in stenosis areas. This feature eliminates the frustration of having the sleeve fall off while you are in the middle of a project. The Functional head of the Flexible Screwdriver comes with a lock and a magnetic device to ensure that the sleeve remains in place while in use. It comes with a 1/4" hex shank quick-connect handle that can fit all drills and wrenches, making it an essential tool in your toolbox. With the Flexible Screwdriver, you can easily twist screws, nuts, and drills in tight and narrow spaces. This magical tool comes with a flexible drill bit extension and a right angle drill adapter, which can also be split for even more flexibility and convenience. Introducing the Flexible Screwdriver, a versatile tool that can connect to your drill, rechargeable drill, electric screwdriver, or manual wrench to extend their reach to inaccessible areas. 2. Flexi-Drill: The Ultimate Extension Solution ![]() It's also easy to use and requires no special skills or training to operate. It's durable and can withstand heavy use, making it a great investment for any DIY enthusiast or professional contractor. Made from high-quality materials, the Magnetic Bit Holder is built to last. Plus, the flexible shaft allows you to easily maneuver around corners and obstacles, making your job easier and more efficient. Its magnetic tip keeps your fasteners in place so you don't have to worry about losing them while working. Whether you're working under cabinetry, behind entertainment systems, or on cars, the Magnetic Bit Holder is the ideal tool for hard to reach places. This makes it ideal for use with power tools made by Ryobi and other brands that use a 1/4 inch chuck. The shaft is slip-proof, ensuring that it stays stable while the rest of the system shakes as a drill should. With a flexible shaft that can bend up to 90 degrees, you can easily get into tight spots that would be impossible to reach otherwise. The Magnetic Bit Holder is the perfect tool for keeping your fasteners secure while working. So, if you’re ready to add this versatile tool to your kit, start exploring your options today! 10 Best Flexible Drill Bit Extension What size and length do I need for my project? Do I need a flexible extension or a more rigid one? What is my budget? By taking the time to consider these factors, you can ensure that you select the best flexible drill bit extension for your needs and get the job done with ease. To help you make an informed decision when selecting a flexible drill bit extension, ask yourself some key questions. You’ll also want to consider the material and construction of the extension, as these factors can affect durability and performance. Different drill bit extensions will have varying degrees of flexibility, length, and diameter, so it’s important to select one that will suit your specific drilling needs. Firstly, you’ll want to think about the intended application of the tool. But with so many options available on the market, how do you choose the best flexible drill bit extension for your needs?īefore making a purchase, there are a few factors to consider. These handy accessories allow you to reach tight and confined spaces with ease, giving you added flexibility and control when drilling. If you’re looking for a versatile and practical tool to add to your toolkit, a flexible drill bit extension might just be the perfect solution. ![]() ![]() ![]() ![]() Improvements in the Carolina offensive line have also aided Newton, with the team allowing only 12 sacks. The result? Newton has currently completed a career-high 67.3 per cent of his passes this season, compared to his seven-year career average of 59.0. The Panthers also have the edge at running back with a healthy Jonathan Stewart to go with Newton to lead a ground attack that has rushed for at least 100 yards in 29 straight games. He is second only to Christian McCaffery in rushing yards for the Panthers this season.Īnd, rather than attempt to turn Newton into a pocket passer, as many have tried - and failed - to do previously, Turner has looked to gradually ease in such components, such as introducing more check-down passes than the team have previously been accustomed to. Newton has always been as likely to throw from the pocket as he is to pick up yards running the football. New Panthers offensive coordinator Norv Turner has undoubtedly had an effect on Newton, with the former San Diego Chargers head coach, and veteran NFL offensive guru, honing his new quarterback's skills rather than looking to change them. Highlights from the NFL as Baltimore Raves took on Carolina Panthers in Week 8. A mixed 3-2 start has been followed by a three-game win streak in which they have downed the defending champion Philadelphia Eagles, the Baltimore Ravens and their No 1 defense and then ran up the score against divisional rivals Tampa Bay Buccaneers. As confidence in the Panthers grew, the line swelled to six points this. A win against the in-form Pittsburgh Steelers - who are on a four-match winning streak - when the two meet on Thursday Night Football would confirm the Panthers are capable of making another such run in the playoffs.Īny doubts over whether Newton and this Carolina team are capable of going deep into the postseason have been dispelled over the past few weeks. The Panthers opened as 3.5-point favorites to beat the Broncos in Super Bowl 50. This year, Newton looks to have rediscovered the 2015 flair and form which helped lead Carolina to the Super Bowl promised land. And, while he threw two touchdowns in the Wild Card playoff defeat against the New Orleans Saints, the Panthers were still beaten by their division rivals. He finished 2016 with a career-worst 52.9 pass completion percentage, having thrown 14 interceptions - the second-most of his six-year career at that stage.Īlthough the 2017 season saw an improvement from the Panthers - an 11-5 regular season record - Newton still fell below the high standards he set two years previous. Whether or not he ends the season undefeated, Cam Newton will always be number one on the field, and number one in our hearts.Newton fell far short of the heights he hit the previous year. With only three games left in the season, can the Panthers maintain their undefeated record? And could this year be their first Super Bowl win? Cam Newton (1) with the ball during PanthersSaints game in. Newton also became the first rookie quarterback to pass for over 4,000 yards in a season. On many occasions, both opponents and referees have tried to stop him from handing out the ball, but in the end, Newton always gets it into a fan’s hands. Longest win streak: Panthers, 4 (200204 200507) Saints, 5 (200002) Current win streak: Saints, 2 (2023present) Championship success Super Bowl championships (1). He dabs and supermans before retrieving the football and handing it to a lucky fan. He has totaled 31,698 passing yards, 190 passing touchdowns, 5,398 rushing yards and 70 rushing scores with the Panthers, as well as holding franchise records for quarterback wins (68), passing. To celebrate each of his touchdowns, Newton has a somewhat elaborate dance. (Of course, Newton still uses his arm, passing 25 touchdowns this season.) Newton has rushed seven touchdowns this season and surpassed Michael Vick’s record of 36 with his own record of 40. ![]() And after losing four of their wide receivers, no one thought they would emerge undefeated.įortunately, Cam Newton does not seem to need one. Having never won a Super Bowl and only seen a playoff game seven times, the Panthers have never been the fan favorite. Number one in the draft, on the field, and in the NFC South, Cam Newton has been dominating the 2015 NFL season after leading his team with a 13-0 record. The Carolina Panthers were considered the underdog of their league at the beginning of the season. ![]() ![]() ![]() These actions can then be repeated automatically by running the macro. The Macro Recorder records actions of the user and generates VBA code in the form of a macro. Ī common and easy way to generate VBA code is by using the Macro Recorder. VBA was restored in the next version, Mac Excel 2011, although the build lacks support for ActiveX objects, impacting some high level developer tools. VBA was removed from Mac Excel 2008, as the developers did not believe that a timely release would allow porting the VBA engine natively to Mac OS X. The user can implement numerical methods as well as automating tasks such as formatting or data organization in VBA and guide the calculation using any desired intermediate results reported back to the spreadsheet. Programmers may write code directly using the Visual Basic Editor (VBE), which includes a window for writing code, debugging code, and code module organization environment. Programming with VBA allows spreadsheet manipulation that is awkward or impossible with standard spreadsheet techniques. The Windows version of Excel supports programming through Microsoft's Visual Basic for Applications (VBA), which is a dialect of Visual Basic. Subroutine in Excel calculates the square of named column variable x read from the spreadsheet, and writes it into the named column variable y. The function sq is introduced using the Visual Basic editor supplied with Excel. The named variables x & y are identified in the Name Manager. Main article: Visual Basic for Applications Use of a user-defined function sq(x) in Microsoft Excel. Microsoft allows for a number of optional command-line switches to control the manner in which Excel starts. Excel was not designed to be used as a database. In a more elaborate realization, an Excel application can automatically poll external databases and measuring instruments using an update schedule, analyze the results, make a Word report or PowerPoint slide show, and e-mail these presentations on a regular basis to a list of participants. It also has a variety of interactive features allowing user interfaces that can completely hide the spreadsheet from the user, so the spreadsheet presents itself as a so-called application, or decision support system (DSS), via a custom-designed user interface, for example, a stock analyzer, or in general, as a design tool that asks the user questions and provides answers and reports. It has a programming aspect, Visual Basic for Applications, allowing the user to employ a wide variety of numerical methods, for example, for solving differential equations of mathematical physics, and then reporting the results back to the spreadsheet. It does this by simplifying large data sets via PivotTable fields. ![]() A PivotTable is a tool for data analysis. It allows sectioning of data to view its dependencies on various factors for different perspectives (using pivot tables and the scenario manager). ![]() In addition, it can display data as line graphs, histograms and charts, and with a very limited three-dimensional graphical display. It has a battery of supplied functions to answer statistical, engineering, and financial needs. Microsoft Excel has the basic features of all spreadsheets, using a grid of cells arranged in numbered rows and letter-named columns to organize data manipulations like arithmetic operations. ![]() ![]() ![]() SoundCloud: Millions of underground and premium tracks SoundCloud Go+).TIDAL: Millions of tracks, music videos, high quality sound /TIDAL Premium or HiFi).Extensive content library with 1000+ loops and samples.Beat-matched sequencing of drums and samples. ![]()
![]() ![]() ![]() AUTOMATICALLY IDENTIFY FACES IN PHOTOSĪI Enhancer, also known as AI Photo Enhancer, can instantly and automatically recognize your face in any photograph you take, whether it is of you or a group of people. You are free to make any changes to the brightness, saturation, and other settings that you see fit to achieve the desired look. You can also change the image’s color to reflect your personal preferences by applying the best effect for yourself. You have the explicit right to edit any image to make it clearer or blurrier, depending on the individual’s usage and goals for the image. If the resolution is increased by 200%, 500%, or even more, every user will have access to crisp and beautiful images. You can either repair or replace older images with more recent versions of the same image to make them more appealing.ĪI Enhancer and AI Photo Enhancer allow users to easily increase the image resolution of any image they choose, ensuring that the final product has both the clarity and resolution that the user desires. The application in question produces results of such high quality that you will be astounded by them. Photos taken ten or even twenty years ago can be converted into vibrant, smooth images with HD quality. You can breathe new life into your images by utilizing the advanced technology included in the application. Users of AI Enhancer or AI Photo Enhancer can restore and repair photographs that have become faded or scratched to their original glory and beauty. You will be able to appreciate the many stunning visual products it provides because it employs cutting-edge AI technology. ![]() The efficiency with which low-quality images can be converted to high-quality HD is unparalleled. The app’s social features, such as following other users, liking and commenting on videos, and sharing videos, allow users to connect with others and discover new content.This application will allow you to enhance and correct blurry photos quickly. The app is easy to use, and its various features and editing tools allow users to create visually appealing short videos. The overall experience of using the Wink-Video Retouching Tool app by Meitu China Limited can be described as fun and engaging. However, the user of this app base is primarily concentrated in Asia, which means that users outside of Asia may have limited interaction and engagement with other users. ![]() This tool also sends notifications to you when you receive new followers, likes, or comments on their videos. You can also follow other users on the platform to stay updated with their content and engage with them. The app's Discover feature allows you to browse and discover new content from popular creators and trending topics. You can share your videos on the app or other social media platforms like Facebook, Instagram, and Twitter. You can also add music to your videos from the app's licensed music library or their own music collection.įurther, this platform provides a range of editing tools, such as video trimming, cropping, and merging, that you can use to fine-tune your videos. You can add stickers and emojis to your videos to make them more engaging and fun. It offers a variety of filters and effects that you can apply to your videos to enhance them. With Wink-Video Retouching Tool, you can record short videos using the app's built-in camera. ![]() |
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